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Special Conditions

54%* of your patients may be at risk for adverse events if you’re not considering their comorbidities when recommending an analgesic1

Acetaminophen is safe when used as directed for a wide range of patients, including those on aspirin heart therapy, those with a history of stomach problems, and those with kidney dysfunction.2-7 Plus, it can provide effective post-op pain relief when added to a multimodal pain-management plan.8

NSAIDs may interfere with some medications used for CV disease.2,9,10

83% of patients experience side effects from opioid use.11†

NSAIDs may increase the risk of GI bleeding.12

NSAIDs may have adverse renal effects in some patients.13

*Percentage of consumers age 45+ who have high blood pressure, kidney disease, or are taking low-dose aspirin for heart health and thus may not be appropriate to use NSAIDs.

Based on a 2016, 500-person survey in patients who had orthopedic surgery.

REFERENCES: 1. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. Fort Washington, PA; 2017. 2. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 3. Hoftiezer JW, O’Laughlin JC, Ivey KJ. Effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut. 1982;23(8):692-697. 4. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat. 2000;5(2):137-142. 5. Frech EJ, Go MF. Treatment and chemoprevention of NSAID-associated gastrointestinal complications. Ther Clin Risk Manag. 2009;5(1):65-73. 6. Prescott LF, Speirs GC, Critchley JA, Temple RM, Winney RJ. Paracetamol disposition and metabolite kinetics in patients with chronic renal failure. Eur J Clin Pharmacol. 1989;36(3):291-297. 7. Martin U, Temple RM, Winney RJ, Prescott LF. The disposition of paracetamol and the accumulation of its glucuronide and sulphate conjugates during multiple dosing in patients with chronic renal failure. Eur J Clin Pharmacol. 1991;41(1):43-46. 8. Chou R, Gordon DB, de Leon-Casasola OA, et al. Management of Postoperative Pain: A Clinical Practice Guideline From the American Pain Society, the American Society of Regional Anesthesia and Pain Medicine, and the American Society of Anesthesiologists’ Committee on Regional Anesthesia, Executive Committee, and Administrative Council. J Pain. 2016;17(2):131-157. 9. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 10. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107:628-635. 11. Data on file. Pacira Pharmaceuticals. Plan against pain. Opioid addiction and dependence after surgery is significantly higher than previously known. 2016. 12. Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Circulation. 2008;118(8):1894-1909. 13. Bugge JF. Renal effects and complications of NSAIDs for routine post-operative pain relief: increased awareness of a real problem is needed. Bailliere’s Clinical Anesthesiology. 1995;9(3):483-492.