54%* of your patients may be at risk for adverse events if you’re not considering their comorbidities when recommending an analgesic1
Acetaminophen is safe when used as directed for a wide range of patients, including those on aspirin heart therapy, those with a history of stomach problems, and those with kidney dysfunction.2-8 Since every patient’s situation is different, experts recommend creating individualized pain management plans based on each patient’s goals.9 Consider taking a well-rounded approach that includes both pharmacologic and nonpharmacologic modalities.10
*Percentage of consumers age 45+ who have high blood pressure, kidney disease, or are taking low-dose aspirin for heart health and thus may not be appropriate to use NSAIDs.
†In patients with kidney dysfunction.
REFERENCES: 1. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. Fort Washington, PA; 2017. 2. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 3. Hoftiezer JW, O’Laughlin JC, Ivey KJ. Effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut. 1982;23(8):692-697. 4. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat. 2000;5(2):137-142. 5. Frech EJ, Go MF. Treatment and chemoprevention of NSAID-associated gastrointestinal complications. Ther Clin Risk Manag. 2009;5(1):65-73. 6. Prescott LF, Speirs GC, Critchley JA, Temple RM, Winney RJ. Paracetamol disposition and metabolite kinetics in patients with chronic renal failure. Eur J Clin Pharmacol. 1989;36(3):291-297. 7. Martin U, Temple RM, Winney RJ, Prescott LF. The disposition of paracetamol and the accumulation of its glucuronide and sulphate conjugates during multiple dosing in patients with chronic renal failure. Eur J Clin Pharmacol. 1991;41(1):43-46. 8. Naproxen. US National Library of Medicine. Revised September 15, 2015. Accessed June 15, 2016. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a681029.html 9. Institute for Healthcare Improvement. Advancing the safety of acute pain management. 2019. Accessed October 16, 2020. http://www.ihi.org/resources/Pages/Publications/ Advancing-the-Safety-of-Acute-Pain-Management.aspx 10. US Department of Health and Human Services. Pain Management Best Practices Inter-Agency Task Force Report: Updates, Gaps, Inconsistencies, and Recommendations. May 9, 2019. Accessed October 23, 2020. https://www.hhs.gov/sites/default/files/pmtf-final-report-2019-05-23.pdf 11. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 12. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107(5):628-635. 13. Abraham NS, Hlatky MA, Antman EM, et al. ACCF/ACG/AHA 2010 expert consensus document on the concomitant use of proton pump inhibitors and thienopyridines: a focused update of the ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Circulation. 2010;122:2619-2633. 14. Kovac SH, Saag KG, Curtis JR, Allison J. Association of health-related quality of life with dual use of prescription and over-the-counter nonsteroidal antiinflammatory drugs. Arthritis Rheum. 2008;59(2):227-233. 15. Bugge JF. Renal effects and complications of NSAIDs for routine post-operative pain relief: increased awareness of a real problem is needed. Baillieres Clin Anaesthesiol. 1995;9(3):483-492.
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