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TYLENOL® may be an appropriate analgesic for patients with certain comorbidities1-8

54%* of your patients may be at risk for adverse events if you’re not considering their comorbidities when recommending an analgesic9

Acetaminophen is safe when used as directed for a wide range of patients, including those on aspirin heart therapy, those with a history of stomach problems, and those with kidney dysfunction.1,4-8

Cardiovascular disease icon

Cardiovascular disease

NSAIDs may interfere with some medications used for cardiovascular disease.1,2,10

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Gastrointestinal icon

Gastrointestinal

NSAIDs may increase risk of GI bleeding.11

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Renal disease icon

Renal disease

NSAIDs may have adverse renal effects in some patients.12

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*Percentage of consumers age 45+ who have high blood pressure, kidney disease, or are taking low-dose aspirin for heart health and thus may not be appropriate to use NSAIDs.

REFERENCES: 1. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 2. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 3. Horn JR, Hansten PD. NSAIDs and antihyperintensive agents. Pharmacy Times. http://www.pharmacytimes.com/publications/issue/2006/2006-04/2006-04-5484. Published April 1, 2006. Accessed January 5, 2017. 4. Hoftiezer JW, O’Laughlin JC, Ivey KJ. Effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut. 1982;23(8):692-697. 5. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat. 2000;5(2):137-142. 6. Frech EJ, Go MF. Treatment and chemoprevention of NSAID-associated gastrointestinal complications. Ther Clin Risk Manag. 2009;5(1):65-73. 7. Prescott LF, Speirs GC, Critchley JA, Temple RM, Winney RJ. Paracetamol disposition and metabolite kinetics in patients with chronic renal failure. Eur J Clin Pharmacol. 1989;36(3):291-297. 8. Martin U, Temple RM, Winney RJ, Prescott LF. The disposition of paracetamol and the accumulation of its glucuronide and sulphate conjugates during multiple dosing in patients with chronic renal failure. Eur J Clin Pharmacol. 1991;41(1):43-46. 9. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. Fort Washington, PA; 2017. 10. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107:628-635. 11. Bhatt DL, Scheiman J, Abraham NS, et al. ACCF/ACG/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use. Circulation. 2008;118(8):1894-1909. 12. Bugge JF. Renal effects and complications of NSAIDs for routine post-operative pain relief: increased awareness of a real problem is needed. Bailliere’s Clinical Anesthesiology. 1995;9(3):483-492.