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Efficacy of TYLENOL®

The efficacy of TYLENOL® has been well supported by clinical studies and decades of actual use.

TYLENOL® is the #1 doctor-recommended brand of pain reliever—and the brand that hospitals use most.

At 4 weeks, acetaminophen was shown to be as effective as ibuprofen for short-term symptomatic treatment of OA pain of the knee.1

Overall Stanford Health Assessment Questionnaire pain scores have a range of 0 to 3.

By one-way analysis of variance among the three groups.

No significant differences were observed between the three treatment groups.

Efficacy Osteoarthritis Graph

Adapted from Bradley JD, et al. N Engl J Med. 1991;325(2):87-91.

Analgesic efficacy at 1000 mg and 650 mg3

Acetaminophen 1000 mg and 650 mg: effective for postoperative dental pain3

In a randomized, double-blind, placebo-controlled, single-dose study, acetaminophen 1000 mg provided significantly greater efficacy in treating postsurgical dental pain compared with acetaminophen 650 mg and placebo.

Efficacy Post-Operative Pain Graph

Adapted from Qi DS, et al. Clin Ther. 2012;31:2217-2258.

Analgesic efficacy in sprains and strains

Acetaminophen extended release 3900 mg/day: comparable to ibuprofen 1200 mg/day for grade I or II lateral ankle sprains

Efficacy Sprains and Strains Graph

Adapted from Dalton JD, et al. Ann Emerg Med. 2006;48(5):615-623.

TYLENOL® Safety line chart

Doctors can recommend up to 4000 mg/day.4

Educate patients on dosing

Remind patients to read every label, every time.

REFERENCES: 1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325(2):87-91. 2. Dalton JD, Schweinle JE. Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. Ann Emerg Med. 2006;48(5):615-623. 3. Qi DS, May LG, Zimmerman B, et al. A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther. 2012;34(12):2247-2258. 4. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. Fort Washington, PA; 2017.