Recommend TYLENOL® 8HR Arthritis Pain

Time-release formulation provides fast and lasting OA pain relief

  • Fast-acting, long-lasting systemic relief of minor arthritis pain—lasts up to 8 hours
  • Proven analgesic efficacy in osteoarthritis (OA)—even when inflammation is present1
  • Does not increase the risk of heart attack, heart failure, or stroke the way ibuprofen or naproxen sodium can2
  • Does not irritate the stomach the way aspirin, naproxen sodium, or even ibuprofen can3-6

See labeled dosages

TYLENOL®: #1 doctor-recommended brand for arthritis pain

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*When used as directed.

†In a study of older adults from the Northeast US.

REFERENCES: 1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. J Rheumatol. 1992;19(12):1950-1954. 2. FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs. U.S. Food and Drug Administration. Accessed January 12, 2018. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm453610.htm 3. Hoftiezer JW, O’Laughlin JC, Ivey KJ. Effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut. 1982;23(8):692-697. 4. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat. 2000;5(2):137-142. 5. Naproxen. National Institues of Health: US National Library of Medicine. Revised September 15, 2015. Accessed June 15, 2016. https://www.nlm.nih.gov/medlineplus/druginfo/meds/a681029.html 6. Frech EJ, Go MF. Treatment and chemoprevention of NSAID-associated gastrointestinal complications. There Clin Risk Manag. 2009;5(1)65-73. 7. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325(2):87-91. 8. Dalton JD, Schweinle JE. Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. Ann Emerg Med. 2006;48(5):615-623. 9. Qi DS, May LG, Zimmerman B, et al. A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther. 2012;34(12):2247-2258. 10. American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009;57(8):1331-1346. 11. Temple AR, Benson GD, Zinsenheim JR, Schweinle JE. Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (6-12 months) safety of acetaminophen in adult patients with osteoarthritis. Clin Ther. 2006;28(2):222-235. 12. Brander V. Changing the treatment paradigm: moving to multimodal and integrated osteoarthritis disease management. J Fam Pract. 2011:60(11):S41-S47. 13. Penninx BWJH, Messier SP, Rejeski WJ, et al. Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis. Arch Intern Med. 2001;161(19):2309-2316. 14. Messier SP, Gutenkunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knew osteoarthritis. Arthritis Rheum. 2005;52(7):2026-2032. 15. Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013;3(5):e002624. 16. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 17. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs: a randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen. Ann Intern Med. 1987;107:628-635. 18. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 19. Kalafutova S, Juraskova B, Vlcek J. The impact of combinations of non-steroidal anti-inflammatory drugs and anti-hypertensive agents on blood pressure. Adv Clin Exp Med. 2014;23(6):993-1000.