Recommend TYLENOL® 8HR Arthritis Pain

Time-release formulation provides fast and lasting OA pain relief

  • Fast-acting, long-lasting systemic relief of minor arthritis pain—lasts up to 8 hours
  • Proven analgesic efficacy in osteoarthritis (OA)—even when inflammation is present1
  • Does not increase the risk of heart attack, heart failure, or stroke the way ibuprofen or naproxen sodium can2
  • Does not irritate the stomach the way aspirin, naproxen sodium, or even ibuprofen can3-6

See labeled dosages

TYLENOL®: #1 doctor-recommended brand for arthritis pain

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*When used as directed.

†In a study of older adults from the Northeast US.

REFERENCES: 1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. J Rheumatol. 1992;19(12):1950-1954. 2. FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs. U.S. Food and Drug Administration. Accessed January 12, 2018. 3. Hoftiezer JW, O’Laughlin JC, Ivey KJ. Effects of 24 hours of aspirin, Bufferin, paracetamol and placebo on normal human gastroduodenal mucosa. Gut. 1982;23(8):692-697. 4. Blot WJ, McLaughlin JK. Over the counter non-steroidal anti-inflammatory drugs and risk of gastrointestinal bleeding. J Epidemiol Biostat. 2000;5(2):137-142. 5. Naproxen. National Institues of Health: US National Library of Medicine. Revised September 15, 2015. Accessed June 15, 2016. 6. Frech EJ, Go MF. Treatment and chemoprevention of NSAID-associated gastrointestinal complications. There Clin Risk Manag. 2009;5(1)65-73. 7. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325(2):87-91. 8. Dalton JD, Schweinle JE. Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. Ann Emerg Med. 2006;48(5):615-623. 9. Qi DS, May LG, Zimmerman B, et al. A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther. 2012;34(12):2247-2258. 10. American Geriatrics Society Panel on Pharmacological Management of Persistent Pain in Older Persons. Pharmacological management of persistent pain in older persons. J Am Geriatr Soc. 2009;57(8):1331-1346. 11. Temple AR, Benson GD, Zinsenheim JR, Schweinle JE. Multicenter, randomized, double-blind, active-controlled, parallel-group trial of the long-term (6-12 months) safety of acetaminophen in adult patients with osteoarthritis. Clin Ther. 2006;28(2):222-235. 12. Brander V. Changing the treatment paradigm: moving to multimodal and integrated osteoarthritis disease management. J Fam Pract. 2011:60(11):S41-S47. 13. Penninx BWJH, Messier SP, Rejeski WJ, et al. Physical exercise and the prevention of disability in activities of daily living in older persons with osteoarthritis. Arch Intern Med. 2001;161(19):2309-2316. 14. Messier SP, Gutenkunst DJ, Davis C, DeVita P. Weight loss reduces knee-joint loads in overweight and obese older adults with knew osteoarthritis. Arthritis Rheum. 2005;52(7):2026-2032. 15. Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013;3(5):e002624. 16. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 17. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs: a randomized, double-blind, placebo-controlled trial of ibuprofen compared with acetaminophen. Ann Intern Med. 1987;107:628-635. 18. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 19. Kalafutova S, Juraskova B, Vlcek J. The impact of combinations of non-steroidal anti-inflammatory drugs and anti-hypertensive agents on blood pressure. Adv Clin Exp Med. 2014;23(6):993-1000.