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Safey and Efficacy of TYLENOL®

The safety and efficacy of TYLENOL® has been well established through clinical studies and decades of actual use.1-3

Proven analgesic efficacy and an outstanding safety profile when used as directed1-5

TYLENOL® offers a wide range of options and may be recommended up to 4000 mg/day safely for a wide range of patients.6

REFERENCES: 1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325(2):87-91. 2. Dalton JD, Schweinle JE. Randomized controlled noninferiority trial to compare extended release acetaminophen and ibuprofen for the treatment of ankle sprains. Ann Emerg Med. 2006;48(5):615-623. 3. Qi DS, May LG, Zimmerman B, et al. A randomized, double-blind, placebo-controlled study of acetaminophen 1000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther. 2012;34(12):2247-2258. 4. Gelotte C, Temple AR, Zimmerman BA, Slattery JT. Acetaminophen biotransformation at single and repeat maximum doses is similar between adults with and without chronic liver disease. Poster presented at: 58th Annual Meeting of the American Association for the Study of Liver Disease; November 2007; Boston, MA. 5. Green JL, Kuffner EK, Bogdan GM, Dart RC. Hepatic function in alcoholics throughout 5 days of maximal therapeutic dosing of acetaminophen (APAP). Clin Toxicol. 2005;43:683. 6. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. Fort Washington, PA; 2017.