Renal Dysfunction Risk

The National Kidney Foundation recommends acetaminophen as a first-line analgesic for episodic use in patients with underlying renal disease.4

NSAIDs may have adverse renal effects in patients with kidney dysfunction3,5

NSAIDs can affect both cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) in the kidneys. In people with some compromise of renal blood flow, NSAID inhibition of COX-1 in afferent renal arterioles can result in reduced renal perfusion and inhibition of COX-2 can promote sodium and fluid retention.3,5

When taken at recommended doses, TYLENOL® does not compromise renal function in patients with existing kidney dysfunction.1-3

See how NSAIDs can effect the kidneys5

In kidneys with some degree of dysfunction, NSAIDs’ cyclooxygenase inhibition may compromise renal function and promote fluid retention.5

26 Million Adults Have Renal Disorder

Millions of adults have kidney dysfunction6

NSAIDs may precipitate acute renal failure in some patients, including the elderly and those with5:

  • Preexisting renal insufficiency
  • Hypertension
  • Congestive heart failure
  • Diabetes
  • Hepatic cirrhosis
  • Sepsis
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REFERENCES: 1. Prescott LF, Speirs GC, Critchley JA, Temple RM, Winney RJ. Paracetamol disposition and metabolite kinetics in patients with chronic renal failure. Eur J Clin Pharmacol. 1989;36(3):291-297. 2. Martin U, Temple RM, Winney RJ, Prescott LF. The disposition of paracetamol and the accumulation of its glucuronide and sulphate conjugates during multiple dosing in patients with chronic renal failure. Eur J Clin Pharmacol. 1991;41(1):43-46. 3. Weir MR. Renal effects of nonselective NSAIDs and coxibs. Cleve Clin J Med. 2002(69 Suppl 1):S153-S158. 4. Henrich WL, Agodoa LE, Barrett B, et al. Analgesics and the kidney: summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the National Kidney Foundation. Am J Kidney Dis. 1996;27:162-165. 5. Bugge JF. Renal effects and complications of NSAIDs for routine post-operative pain relief: increased awareness of a real problem is needed. Bailliere’s Clinical Anesthesiology. 1995;9(3):483-492. 6. National Kidney Foundation. Kidney disease: the basics. Updated February 2017. Accessed February 24, 2017