When matters of the heart matter most, recommend TYLENOL®

TYLENOL® may be a good analgesic choice for patients with certain cardiovascular conditions1

92.1 million American adults have at least one type of cardiovascular disease2

When recommending an analgesic, it’s important to consider patients’ heart risks. The combination of certain pain relievers with some medicinal therapies can interfere with cardiovascular treatment. Because of its safety and analgesic efficacy, the American Heart Association has identified acetaminophen as a first-line pain relief option for patients with, or at high risk for, cardiovascular disease.3*

Nearly half of all US adults are hypertensive4

Even after diagnosis, 65% of hypertensive patients surveyed used NSAIDs or a medicine other than acetaminophen most often for pain or fever.5 NSAIDs may affect blood pressure, putting these patients at increased risk.6-9

Watch how NSAIDs can affect the kidneys and increase blood pressure—and see how TYLENOL® works differently6-9

NSAIDs, like ibuprofen, can increase blood pressure and the risk of heart attack and stroke6

NSAIDs can affect both COX-1 and COX-2 in the kidneys. In people with some compromise of renal blood flow, NSAID inhibition of COX-1 constricts blood flow to the kidneys and can result in reduced renal perfusion. Inhibition of COX-2 can promote sodium and fluid retention.8,9

NSAIDs can interact with certain antihypertensives, such as diuretics and ACE inhibitors6,7

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More than 45% of patients with high blood pressure take an antihypertensive that can interact with NSAIDs10

Patients who take an antihypertensive and an NSAID together may experience decreased antihypertensive efficacy.6-9

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Over 80% of patients surveyed with high blood pressure are unaware that NSAIDs can interfere with antihypertensives5

NSAIDs can interfere with the blood pressure-lowering efficacy of diuretics and ACE inhibitors.11

TYLENOL® won’t compromise blood pressure control or interfere with certain high blood pressure medications the way NSAIDs sometimes can6,7

Visit the Resource Library to explore patient and practice support resources.

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TYLENOL® is an appropriate analgesic choice for patients with hypertension.6,12

Updated NSAID warnings: help your patients understand risks

The U.S. Food and Drug Administration (FDA) required an update to the Drug Facts labeling of all adult and pediatric non-aspirin OTC nonsteroidal anti-inflammatory drugs (NSAIDs), for example Motrin®, Advil®, and Aleve® products. These strengthen and expand existing warnings relating to the risk of heart attack and stroke associated with NSAIDs.13

TYLENOL® does not have a cardiovascular risk warning on its label

Download the NSAID Warning Comparison Guide for more information.


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*When symptoms are not controlled by nonpharmacological approaches.
†2016 consumer survey conducted for Johnson & Johnson Consumer Inc. among patients aged 45+. Data on file.

REFERENCES: 1. Catella-Lawson F, Reilly MP, Kapoor SC, et al. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. N Engl J Med. 2001;345(25):1809-1817. 2. American Heart Association. Heart disease and stroke statistics 2017 at-a-glance. https://healthmetrics.heart.org/wp-content/uploads/2017/06/Heart-Disease-and-Stroke-Statistics-2017-ucm_491265.pdf. Accessed January 12, 2018. 3. Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA. Use of nonsteroidal anti-inflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115(12):1634-1642. 4. American College of Cardiology. New ACC/AHA high blood pressure guidelines lower definition of hypertension. http://www.acc.org/latest-in-cardiology/articles/2017/11/08/11/47/mon-5pm-bp-guideline-aha-2017. Accessed January 12, 2018. 5. Data on file. Johnson & Johnson Consumer Inc., McNeil Consumer Healthcare Division. 2017. 6. Elliott WJ. Drug interactions and drugs that affect blood pressure. J Clin Hypertens. 2006;8(10):731-737. 7. Radack KL, Deck CC, Bloomfield SS. Ibuprofen interferes with the efficacy of antihypertensive drugs. Ann Intern Med. 1987;107:628-635. 8. Bugge JF. Renal effects and complications of NSAIDs for routine post-operative pain relief: increased awareness of a real problem is needed. Bailliere’s Clinical Anesthesiology. 1995;9(3):483-492. 9. Weir MR. Renal effects of nonselective NSAIDs and coxibs. Cleve Clin Q. 2002;69 Suppl 1:SI53-SI58. 10. Miller GE, Doshi A. Diuretic use in the treatment of hypertension, by selected population characteristics, 2003. Medical Expenditure Panel Survey. Statistical Brief #119. 2006. 11. Kalafutova S, Juraskova B, Vlcek J. The impact of combinations of non-steroidal anti-inflammatory drugs and anti-hypertensive agents on blood pressure. Adv Clin Exp Med. 2014;23(6):993-1000. 12. Horn JR, Hansten PD. NSAIDs and antihypertensive agents. Pharmacy Times. 2006. http://www.pharmacytimes.com/publications/issue/2006/2006-04/2006-04-5484. Published April 2, 2006. Accessed January 5, 2017. 13. U.S. Food and Drug Administration. FDA strengthens warning of heart attack and stroke risk for non-steroidal anti-inflammatory drugs. https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm453610.htm. Accessed January 12, 2018. 14. Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a cross-sectional study. BMJ Open. 2013;3(5):e002624.