TYLENOL®: Analgesic efficacy in osteoarthritis—even with inflammation present

Acetaminophen 4000 mg/day is as effective as Rx doses of ibuprofen (2400 mg/day) and the maximum OTC dose of ibuprofen (1200 mg/day) for OA of the knee.2

Results as measured by patient-assessed pain scores at 4 weeks.

How many of your patients with OA also have heart disease?

Nearly 1 in 4 arthritis patients have heart disease

TYLENOL®: An appropriate choice for OA patients with heart disease5

The American Heart Association recommends acetaminophen as a first-line analgesic for patients with known cardiovascular disease.*5

*When symptoms are not controlled by nonpharmacological approaches.

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REFERENCES: 1. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Treatment of knee osteoarthritis: relationship of clinical features of joint inflammation to the response to a nonsteroidal antiinflammatory drug or pure analgesic. J Rheumatol. 1992;19(12):1950-1954. 2. Bradley JD, Brandt KD, Katz BP, Kalasinski LA, Ryan SI. Comparison of an anti-inflammatory dose of ibuprofen, an analgesic dose of ibuprofen, and acetaminophen in the treatment of patients with osteoarthritis of the knee. N Engl J Med. 1991;325(2):87-91. 3. CDC. Comorbidities, 2015. Atlanta, GA: U.S. Department of Health and Human Services, CDC; 2005.  4. Rahman MM, Kopec JA, Cibere J, Goldsmith CH, Anis AH. The relationship between osteoarthritis and cardiovascular disease in a population health survey: a crosssectional study. BMJ Open. 2013;3(5):e002624 5. Antman EM, Bennett JS, Daugherty A, Furberg C, Roberts H, Taubert KA. Use of nonsteroidal anti-inflammatory drugs: an update for clinicians: a scientific statement from the American Heart Association. Circulation. 2007;115(12):1634-1642.