Acetaminophen Clinical Guidelines and Studies

These links and downloads include guidelines on acetaminophen's role in pain management and useful overviews of TYLENOL® products.

Professional Guidelines on Pain Management

These organizations have recommended acetaminophen as a first–line treatment for a range of conditions:

Osteoarthritis Pain

"For many patients with OA, acetaminophen is conditionally recommended as a first-line treatment for pain relief of the knee or hip."

Persistent Pain in Older Adults

"Owing to its greater safety than traditional NSAIDs, acetaminophen is recommended as a first-line therapy for management of osteoarthritis and lower back pain in older adults."

In Musculoskeletal Pain in Known Cardiovascular Disease

Acetaminophen is recommended for musculoskeletal symptoms with known cardiovascular disease or risk factors for ischemic heart disease.

*The American College of Rheumatology is an independent professional, medical, and scientific society that does not guarantee, warrant, or endorse any commercial product or service.

Acetaminophen Studies

Efficacy of Acetaminophen 1,000 mg vs Acetaminophen 650 mg
In a randomized, double-blind, placebo-controlled, single-dose study, acetaminophen 1,000 mg provided significantly greater efficacy in treating postsurgical dental pain compared with acetaminophen 650 mg and placebo.

Qi DS, May LG, Zimmerman B, et al. A randomized, double-blind, placebo-controlled study of acetaminophen 1,000 mg versus acetaminophen 650 mg for the treatment of postsurgical dental pain. Clin Ther. 2012;34(12):2247-2258.

Management of Acetaminophen Overdose

Guidelines for the Management of Acetaminophen Overdose
McNeil Consumer Healthcare
Nomogram for acute acetaminophen overdose
McNeil Consumer Healthcare

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