TYLENOL®: Analgesic Efficacy and Osteoarthritis Pain Management
After more than 50 years of use and scientific investigation, TYLENOL® has been shown to provide a rare balance of analgesic efficacy and safety when used as directed.
TYLENOL® is the #1 BRAND OF OTC PAIN RELIEVER RECOMMENDED BY PHYSICIANS
Our Legacy in Osteoarthritis OA Pain Management
The effectiveness of TYLENOL® is seen most dramatically in OA pain management. The main ingredient in TYLENOL®, acetaminophen, is endorsed as a first-line therapy against mild-to-moderate OA pain, as outlined by these expert guidelines:
- American College of Rheumatology* (ACR)
- - Established 1995
- - Re-endorsed 2000
- American Academy of Orthopaedic Surgeons (AAOS)
- American Geriatrics Society (AGS)
- American Pain Society (APS)
- American Heart Association (AHA)
*The American College of Rheumatology is an independent professional, medical, and scientific society that does not guarantee, or endorse in any commercial product or service.
Experts endorsed acetaminophen for mild-to-moderate OA pain, in part, because these clinical studies showed TYLENOL® was:
- As effective as Rx and OTC ibuprofen for mild-to-moderate OA pain (See study)
- Even in the presence of inflammation (See study)
- As effective as naproxen in relieving pain and stiffness (See study)
- As effective as celecoxib in the treatment of mild-to-moderate OA pain (See study)

